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Your Vote Counts! KYMERA THERAPEUTICS, INC. 2022 Annual Meeting Vote by June 14, 2022 11:59 PM ET KYMERA THERAPEUTICS, INC. 200 ARSENAL YARDS BLVD., SUITE 230 WATERTOWN, MA 02472 D80761-P72813 You invested in KYMERA THERAPEUTICS, INC. and its time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy materials for the shareholder meeting to be held on June 15, 2022. Get informed before you vote View the Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by request prior to June 1, 2022. If you would like to request a copy of the material(s) for this and/or future shareholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. For complete information and to vote, visit Control # Smartphone users Vote Virtually at the Meeting * Point your camera here and June 15, 2022 9:00 AM, ET vote without entering a control number Virtually at: * Please check the meeting materials for any special requirements for meeting attendance. V1.1


Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming shareholder meeting. Please follow the instructions on the reverse side to vote these important matters. Voting Items Board Recommends 1. To elect two class II directors to our Board of Directors, to serve until the 2025 Annual Meeting of Shareholders and until his or her successor has been duly elected and qualified, or until his or her earlier death, resignation or removal; Nominees: For 01) Jeffrey Albers, J.D., MBA 02) Joanna Horobin, M.B., Ch.B. 2. To approve, on a non-binding advisory basis, the compensation of our named executive officers; For 3. To recommend, on a non-binding, advisory basis, the preferred frequency of future advisory votes on the compensation 1 Year of our named executive officers; 4. To ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2022; and For NOTE: To transact any other business properly brought before the Annual Meeting or any adjournment or postponement of the Annual Meeting. Prefer to receive an email instead? While voting on, be sure to click Sign up for E-delivery. D80762-P72813