2019 Lease
Two Thousand Nineteen Lease [Member]
Two Thousand Nineteen Lease [Member]
Lease Expiration Date
Lease expiration date
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period
Share-based compensation vesting period
Temporary Equity, Shares Authorized
Convertible Preferred Stock, authorized
Operating Expenses [Abstract]
Operating expenses:
Base Rent
Rental And Lease Expenses
Rental And Lease Expenses
Operating Income (Loss)
Loss from operations
Available-for-sale securities, credit losses
Available-for-sale Securities, Gross Realized Losses
Entity Emerging Growth Company
Entity Emerging Growth Company
Preferred Stock [Text Block]
Convertible Preferred Stock
Income Tax Disclosure [Abstract]
Financial Instrument [Axis]
Financial Instrument
Proceeds from Stock Plans
Proceeds from employee stock purchase plan
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Shares remaining available for future grants
Payments to Acquire Property, Plant, and Equipment
Purchase of property and equipment, net
Payments to Acquire Property, Plant, and Equipment, Total
Geographical [Axis]
Geographical
Common stock, $0.0001 par value; 150,000,000 shares authorized as of March 31, 2022 and December 31, 2021, 51,716,194 and 51,573,924 shares issued at March 31, 2022 and December 31, 2021, respectively; 51,692,666 and 51,536,181 shares outstanding at March 31, 2022 and December 31, 2021, respectively
Common stock, $0.0001 par value; 150,000,000 shares authorized as of September 30, 2021 and December 31, 2020, 51,311,921 and 44,592,288 shares issued at September 30, 2021 and December 31, 2020, respectively; 51,256,553 and 44,482,186 shares outstanding at September 30, 2021 and December 31, 2020, respectively
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Entity Address, State or Province
Entity Address, State or Province
Liabilities
Total liabilities
Unrealized loss on marketable securities
Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent
Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent, Total
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Marketable Securities [Line Items]
Marketable Securities [Line Items]
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Fair value assets level 1 to level 3 transfers amount.
Fair Value Assets Level1 To Level3 Transfers Amount
Fair value assets, level 1 to level 3 transfers, amount
Stockholders' Equity, Reverse Stock Split
Reverse stock split, description
Upfront payment.
Upfront Payment
Upfront payment
Class of Stock [Domain]
Class of Stock
Non refundable upfront payment received.
Non Refundable Upfront Payment Received
Non refundable upfront payment received
Convertible Preferred Stock, Shares Issued upon Conversion
Shares issued upon exchange of Series A convertible preferred stock
Unrealized gain (loss) on marketable securities
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Weighted Average Number of Shares Outstanding, Basic and Diluted
Weighted average common stock outstanding, basic and diluted
Weighted average common shares outstanding, basic and diluted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Investor [Member]
Investor
General and Administrative Expense [Member]
General and Administrative
Exercisable at March 31, 2021
Exercisable at September 30, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Restricted Cash
Restricted cash
Restricted Cash, Total
Debt Securities, Available-for-sale, Current
Marketable securities (Note 4)
Debt Securities, Available-for-sale, Current, Total
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Contract with Customer, Liability, Revenue Recognized
Revenue recognized recorded in deferred revenue
Schedule of Related Party Transactions, by Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Other Liabilities, Current
Other current liabilities
Other Liabilities, Current, Total
City Area Code
City Area Code
Scenario potential outcome.
Scenario Potential Outcome [Domain]
Scenario Potential Outcome
Finance lease liability payments due after year four.
Finance Lease Liability Payments Due After Year Four
Thereafter
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Summary of Weighted-Average Assumptions
Temporary Equity, Par or Stated Value Per Share
Convertible Preferred Stock, par or stated value per share
Payments for Repurchase of Initial Public Offering
Payments of offering costs in connection with initial public offering
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Grant Date Fair Value per Share
Schedule of Unvested Restricted Stock Units Roll Forward [Table Text Block]
Summary of Restricted Stock Activity
Available-for-sale Securities, Noncurrent
Long-term investments
Available-for-sale Securities, Noncurrent, Total
US Treasury Securities [Member]
US Treasuries
U.S. Treasury Securities
Development milestone payments.
Development Milestone Payments
Development milestone payments
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change in accounting principle, accounting standards update, adopted
Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Forfeited
Due from Related Parties, Current
Accounts receivable—due from related parties
Due from Related Parties, Current, Total
Stock issued during period value restricted stock vested.
Stock Issued During Period Value Restricted Stock Vested
Vesting restricted stock
Contract with Customer, Liability
Contract Liabilities, Ending balance
Contract Liabilities, Beginning balance
Contract with Customer, Liability, Total
Proceeds from Sale, Maturity and Collection of Investments
Maturities of investments
Proceeds from Sale, Maturity and Collection of Investments, Total
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Diluted Net Loss Per Share Attributable to Common Stockholders Anti-Diluted Effect
Issuance of shares, Shares
Common stock shares issued
Stock Issued During Period, Shares, New Issues
Debt Securities, Available-for-sale
Fair Value
Marketable securities
Debt Securities, Available-for-sale, Total
Finance Lease, Interest Payment on Liability
Operating cash flows used in finance leases
Collaboration target two.
Collaboration Target Two [Member]
Collaboration Target 2
Fair value assets level 3 to level 1 transfers amount.
Fair Value Assets Level3 To Level1 Transfers Amount
Fair value assets, level 3 to level 1 transfers, amount
Proceeds from Issuance of Convertible Preferred Stock
Proceeds from the issuance of Convertible Preferred Stock, net of issuance costs
Proceeds from issuance of convertible preferred stock
Consolidated Entities [Domain]
Consolidated Entities
Accrued Salaries, Current
Payroll and payroll-related
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Issuance of shares under employee stock purchase plan, Shares
Related Party [Domain]
Related Party
Available-for-sale securities, credit losses
Available For Sale Securities Credit Losses
Available for sale securities credit losses.
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in accounting principle, accounting standards update, immaterial effect
Conversion of convertible preferred stock into common stock
Stock Issued During Period, Value, Conversion of Convertible Securities
Income Statement [Abstract]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Other Nonoperating Income (Expense) [Abstract]
Other income (expense):
Net cash used in investing activities
Net Cash Provided by (Used in) Investing Activities
Increase (Decrease) in Due from Related Parties
Receivables—due from related parties
Increase (Decrease) in Due from Related Parties, Total
Temporary equity stock value vesting of series A preferred stock in connection with collaboration arrangement.
Temporary Equity Stock Value Vesting Of Series A Preferred Stock In Connection With Collaboration Arrangement
Vesting of Series A Preferred Stock in connection with collaboration arrangement (Note 5)
Deferred revenue - Vertex.
Deferred Revenue Vertex [Member]
Deferred Revenue - Vertex
Share-based Compensation Arrangement by Share-based Payment Award, Percentage of Outstanding Stock Maximum
Maximum number of shares to be issued, percentage
Series C preferred stock purchase agreement.
Series C Preferred Stock Purchase Agreement [Member]
Series C SPA
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Property, Plant and Equipment, Net
Property and equipment, net (Note 6)
Property and equipment, net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Contract with Customer, Liability, Current
Deferred revenue
Common Stock, Shares, Issued
Common stock, issued
Common Stock, Shares, Issued, Total
Debt Securities, Available-for-sale, Amortized Cost
Amortized Cost
Operating Lease, Right-of-Use Asset
Right-of-use assets, operating leases
Accumulated amortization.
Accumulated Amortization
Accumulated amortization
Security Exchange Name
Security Exchange Name
Significant accounting policies.
Significant Accounting Policies Policy [Text Block]
Significant Accounting Policies
Statistical Measurement [Domain]
Statistical Measurement
Furniture & Fixtures
Furniture and Fixtures [Member]
Net Income (Loss) Available to Common Stockholders, Basic
Net loss attributable to common stockholders
Other Liabilities, Noncurrent
Other non-current liabilities
Other Liabilities, Noncurrent, Total
Accounting Standards Update 2019-12 [Member]
ASU 2019-12
Cash and Cash Equivalents, Fair Value Disclosure
Cash equivalents
Loss Contingency Accrual
Liabilities accrued
Loss Contingency Accrual, Beginning Balance
Loss Contingency Accrual, Ending Balance
Subsequent Event Type [Domain]
Subsequent Event Type
Increase decrease in operating lease liabilities.
Increase Decrease In Operating Lease Liabilities
Operating lease liabilities
Document Period End Date
Document Period End Date
Cost reimbursement payment received.
Cost Reimbursement Payment Received
Cost reimbursement payment received
Restricted Cash, Noncurrent
Restricted cash
Income Statement Location [Axis]
Income Statement Location
Investments [Domain]
Investments
Accrued Liabilities, Current
Accrued expenses (Note 8)
Accrued expenses
Related Party Transaction, Expenses from Transactions with Related Party
Rent expenses
Loss Contingencies [Table]
Loss Contingencies [Table]
Common Stock, Shares Authorized
Common stock, authorized
Operating Lease, Liability, Current
Operating lease liabilities
Related Party [Axis]
Related Party
Supplemental Cash Flow Information [Abstract]
Supplemental disclosure of cash flow activities
Class of Stock [Axis]
Class of Stock
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Expected income tax refund period CARES Act.
Expected Income Tax Refund Period C A R E S Act
Expected income tax refund period CARES Act
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Anti-dilutive stock
2022 (excluding the first quarter)
2021 (excluding the first, second and third quarter)
Finance Lease, Liability, to be Paid, Remainder of Fiscal Year
Rent paid
Payments for Rent
Share based compensation arrangement by share based payment award options granted in period intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Granted In Period Intrinsic Value
Granted
Interest Paid, Excluding Capitalized Interest, Operating Activities
Cash paid for interest
Income tax disclosure.
Income Tax Disclosure [Line Items]
Income Tax Disclosure [Line Items]
Entity Address, Address Line Two
Entity Address, Address Line Two
Current Fiscal Year End Date
Current Fiscal Year End Date
Net increase (decrease) in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period
Revenue remaining research term
Operating Lease, Cost
Operating lease costs
Finance Lease, Liability, Payment, Due
Total minimum lease payments
Marketable securities, non-current
Marketable Securities, Noncurrent
Marketable Securities, Noncurrent, Total
Lab and office equipment.
Lab And Office Equipment [Member]
Lab and Office Equipment Under Finance Right of Use Asset
Assets [Abstract]
Assets
2021 Lease
Two Thousand Twenty One Lease [Member]
Two Thousand Twenty One Lease [Member]
Lesser of potential outcome one.
Lesser of Potential Outcome 1
Lesser Of Potential Outcome One [Member]
Conversion of convertible preferred stock into common stock, Shares
Stock Issued During Period, Shares, Conversion of Convertible Securities
Business Description and Basis of Presentation [Text Block]
Organization and Nature of Business
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
2022
Fair Value, Assets, Level 2 to Level 1 Transfers, Amount
Fair value, assets, level 2 to level 1 transfers, amount
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
US government agencies
US Government Agencies Debt Securities [Member]
Private Placement [Member]
Private Placement
Private Placement
Common Stock, Par or Stated Value Per Share
Common stock, par value
Net operating loss carryforwards year CARES Act.
Net Operating Loss Carryforwards Year C A R E S Act
Net operating loss carryforwards year CARES Act
Shares, Outstanding
Shares, Outstanding, Ending Balance
Shares, Outstanding, Beginning Balance
Additional Paid in Capital, Common Stock
Additional paid-in capital
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
Purchase of property and equipment through finance lease.
Purchase Of Property And Equipment Through Finance Lease
Purchase of property and equipment through finance lease
Net operating loss carryforwards percentage limitations on use CARES Act.
Net Operating Loss Carryforwards Percentage Limitations On Use C A R E S Act
Net operating loss carryforwards percentage limitations on use CARES Act
Remaining research term of collaboration.
Remaining Research Term Of Collaboration
Remaining research term of collaboration
Earliest Tax Year [Member]
Earliest Tax Year
Document Type
Document Type
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Marketable Securities
Preferred stock, $0.0001 par value; 10,000,000 shares authorized as of September 30, 2021 and December 31, 2020; 0 shares issued and outstanding as of September 30, 2021 and December 31, 2020
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Finance Lease, Interest Expense
Interest expense for finance lease liabilities
Operating Lease, Liability, Noncurrent
Operating lease liabilities, net of current portion
Increase decrease in operating lease right-of-use assets.
Increase Decrease In Operating Lease Right Of Use Assets
Operating lease right-of-use assets
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Accrued Liabilities
Assets, Current
Total current assets
Share-based Payment Arrangement, Option [Member]
Stock Options
Options to Purchase Common Stock
Milestone receivable.
Milestone Receivable
Milestone receivable
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Contract with Customer, Receivable, after Allowance for Credit Loss
Accounts receivable and contract assets, Ending balance
Accounts receivable and contract assets, Beginning balance
Contract with Customer, Receivable, after Allowance for Credit Loss, Total
Outstanding
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Income Tax Expense (Benefit)
Income tax expense (benefit)
Income Tax Expense (Benefit), Total
Earnings Per Share, Basic and Diluted
Net loss per share attributable to common stockholders, basic and diluted
Net loss per share, basic and diluted
Earnings Per Share, Basic and Diluted, Total
Watertown, Massachusetts.
Watertown Massachusetts [Member]
Watertown, Massachusetts
Leases [Abstract]
Antidilutive Securities [Axis]
Antidilutive Securities
Offering costs included in accrued liabilities.
Offering Costs Included In Accrued Liabilities
Offering costs included in accrued expenses
Consolidation, Policy [Policy Text Block]
Principles of Consolidation
Loss Contingencies [Line Items]
Loss Contingencies [Line Items]
Lease termination date.
Lease Termination Date
Lease termination date
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Unvested at end of period
Unvested at beginning of period
Operating cash flows used in operating leases
Operating lease payments (proceeds).
Operating Lease Payments Proceeds
Common Stock, Shares, Outstanding
Common Stock, outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Plan Name [Axis]
Plan Name
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Forfeited
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Operating Expenses
Total operating expenses
Initial Public Offering
IPO [Member]
Lease, Cost
Total lease costs
Financial Instruments [Domain]
Financial Instruments
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Unrealized Losses
Outstanding at end of period
Outstanding at beginning of period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Net Cash Provided by (Used in) Operating Activities [Abstract]
Operating activities
Temporary equity, exchange of convertible preferred stock, shares.
Temporary Equity Exchange Of Convertible Preferred Stock Shares
Temporary Equity, Exchange of Series A Convertible Preferred Stock for Series C Preferred Convertible Preferred Stock, Shares
Finance Lease, Liability, Payment, Due [Abstract]
Finance Leases
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Unrealized Gains
Earnings Per Share [Abstract]
Share-based Compensation Arrangement by Share-based Payment Award, Description
Share-based compensation, description
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
2023
Net Income (Loss) Attributable to Parent
Net Loss
Net loss
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Accrued Expenses
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease, discount rate
Research and Development Expense [Member]
Research and Development Expense
Research and Development
Document Fiscal Period Focus
Document Fiscal Period Focus
Temporary Equity, Stock Issued During Period, Value, New Issues
Issuance of Preferred Stock, net of issuance costs
Collaboration agreement transaction price.
Collaboration Agreement Transaction Price
Collaboration agreement transaction price
Accounting Policies [Abstract]
Lab equipment.
Lab Equipment [Member]
Lab Equipment
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Entity Address, Address Line One
Entity Address, Address Line One
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value
Exercised
Intrinsic value of stock options exercised
Debt Securities, Available-for-sale, Sold at Par Value
Sales of marketable securities
Outstanding at beginning of period
Outstanding at end of period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Series B1 preferred stock.
Series B1 Preferred Stock [Member]
Series B-1 Preferred Stock
Finance Lease, Weighted Average Discount Rate, Percent
Finance lease, discount rate
Liabilities, Current
Total current liabilities
2018 stock option and grant plan.
Two Thousand Eighteen Stock Option And Grant Plan [Member]
2018 Plan
Revenue from Contract with Customer, Product and Service [Extensible Enumeration]
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Contract assets
Contract with Customer, Asset, after Allowance for Credit Loss, Current
Contract assets—due from related parties
Contract with Customer, Asset, after Allowance for Credit Loss, Current, Total
Outstanding at beginning of period
Outstanding at end of period
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value
Lessee, Operating Lease, Liability, to be Paid
Total minimum lease payments
Subsequent Event [Table]
Subsequent Event [Table]
Temporary Equity, Carrying Amount, Attributable to Parent
Temporary Equity, Ending Balance
Temporary Equity, Beginning Balance
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized
Number of additional shares authorized
Tenant incentive allowance receivable.
Tenant Incentive Allowance Receivable
Tenant incentive allowance receivable
Convertible Preferred Stock [Member]
Convertible Preferred Stock
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Net cash (used in) provided by operating activities
Net Cash Provided by (Used in) Operating Activities
Debt securities, available-for-sale, contractual maturity of 12 months or longer, number of securities.
Debt Securities Available For Sale Contractual Maturity Of12 Months Or Longer Number Of Securities
Number of available-for-sale debt securities, contractual maturity of greater than 12 months
Increase (Decrease) in Other Operating Assets and Liabilities, Net
Other assets and liabilities
Increase (Decrease) in Other Operating Assets and Liabilities, Net, Total
Total cash, cash equivalents, and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, cash equivalents and restricted cash at end of period
Cash, cash equivalents and restricted cash at beginning of period
Adjustments to additional paid in capital related to temporary equity deemed dividend.
Adjustments To Additional Paid In Capital Related To Temporary Equity Deemed Dividend
Reduction of additional paid-in-capital related to temporary equity deemed dividend
Equity Components [Axis]
Equity Components
Components of Lease Costs
Lease, Cost [Table Text Block]
Tax Period [Axis]
Tax Period
Assets, Current [Abstract]
Current assets:
Variable Lease, Cost
Variable lease costs
Indemnification Agreement [Member]
Indemnified Parties
Entity Registrant Name
Entity Registrant Name
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive loss:
Loss on disposal of property and equipment
Loss on disposal of property and equipment
Loss on disposal of property and equipment
Gain (Loss) on Disposition of Property Plant Equipment, Total
Gain (Loss) on Disposition of Property Plant Equipment
Finance Lease, Liability
Present value of lease liabilities
Finance Lease, Liability, Total
Latest Tax Year [Member]
Latest Tax Year
Entity Interactive Data Current
Entity Interactive Data Current
Entity Address, City or Town
Entity Address, City or Town
Customer [Axis]
Stock issued during period shares restricted stock vested.
Stock Issued During Period Shares Restricted Stock Vested
Vesting restricted stock, Shares
Lessee operating and finance leases.
Lessee Operating And Finance Leases [Text Block]
Leases
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Trading Symbol
Trading Symbol
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Net Cash Provided by (Used in) Investing Activities [Abstract]
Investing activities
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less amounts representing interest or imputed interest
2020 stock option and incentive plan.
Two Thousand Twenty Stock Option And Incentive Plan [Member]
2020 Plan
Local Phone Number
Local Phone Number
Tenant improvements included in other assets.
Tenant Improvements Included In Other Assets
Tenant improvements included in other assets
Stockholders' Equity Attributable to Parent
Ending Balance
Beginning Balance
Total stockholders’ equity
Subsequent Event Type [Axis]
Subsequent Event Type
Organization and nature of business.
Organization And Nature Of Business [Table]
Organization And Nature Of Business [Table]
Weighted Average Strike Price Per Option
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Issued, Total
Assets, Fair Value Disclosure
Total
Statistical Measurement [Axis]
Statistical Measurement
Entity Small Business
Entity Small Business
Loss Contingency, Nature [Domain]
Loss Contingency, Nature
Property and equipment purchases included in accounts payable and accrued expenses.
Property And Equipment Purchases Included In Accounts Payable And Accrued Expenses
Property and equipment purchases included in accounts payable and accrued expenses
Temporary equity stock issued during period shares new issues.
Temporary Equity Stock Issued During Period Shares New Issues
Issuance of Preferred Stock, net of issuance costs, Shares
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Preferred stock issuance premium.
Preferred Stock Issuance Premium
Preferred stock premium
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Fair value of available-for-sale debt securities contractual maturity of less than twelve months.
Fair Value Of Available For Sale Debt Securities Contractual Maturity Of Less Than Twelve Months
Fair value of available-for-sale debt securities, contractual maturity of less than 12 months
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Over-Allotment Option [Member]
Underwriters
Credit Facility [Axis]
Credit Facility
Accrued Liabilities, Current [Abstract]
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, Less than 12 Months, Number of Positions
Number of available-for-sale debt securities, continuous unrealized loss position for less than 12 months
Finance Lease, Liability, Undiscounted Excess Amount
Less amounts representing interest or imputed interest
Balance Sheet Location [Axis]
Balance Sheet Location
Conversion of Stock, Shares Issued
Conversion of stock, shares issued and outstanding
Significant accounting policies.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Commercial milestone payments.
Commercial Milestone Payments
Commercial Milestone Payments
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Schedule of Assets Measured at Fair Value on Recurring Basis
Granted
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Sale of Stock [Domain]
Sale of Stock
Temporary Equity, Shares Issued
Convertible Preferred Stock, issued
Contract with customer asset net deductions.
Contract With Customer Asset Net Deductions
Accounts receivable and contract assets, Deductions
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Organization and nature of business.
Organization And Nature Of Business [Line Items]
Organization and Nature of Business [Line Items]
Plan Name [Domain]
Plan Name
Temporary Equity, by Class of Stock [Table]
Temporary Equity By Class Of Stock [Table]
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
At-the-Market Offerings
At The Market Offerings [Member]
At The Market Offerings Member
Summary of weighted average remaining lease terms and discount rates.
Summary Of Weighted Average Remaining Lease Terms And Discount Rates Table [Text Block]
Summary of Weighted Average Remaining Lease Terms and Discount Rates
Depreciation
Depreciation expense
Depreciation, Total
Payments of Financing Costs
Payments on finance leases
Payments of Financing Costs, Total
Restricted cash fair value.
Restricted Cash Fair Value
Restricted cash
Series C convertible preferred stock.
Series C Convertible Preferred Stock [Member]
Series C Convertible Preferred Stock
Series C Preferred Stock
Issuance of shares
Stock Issued During Period, Value, New Issues
Series A convertible preferred stock.
Series A Convertible Preferred Stock [Member]
Series A Convertible Preferred Stock
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, Less than 12 Months
Aggregate fair value of available-for-sale debt securities, continuous unrealized loss position for less than 12 months
Debt Securities, Available-for-sale, Noncurrent
Marketable securities, non-current (Note 4)
Fair value of available-for-sale debt securities, contractual maturity of greater than 12 months
Share based compensation arrangement by share based payment award aggregate intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Aggregate Intrinsic Value [Abstract]
Aggregate Intrinsic Value
Initial research term of collaboration.
Initial Research Term Of Collaboration
Initial research term of collaboration
Contract with customer liability deductions.
Contract With Customer Liability Deductions
Contract Liabilities, Deductions
Share-based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense, Total
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Premiums and discounts on available for sale marketable securities.
Premiums And Discounts On Available For Sale Marketable Securities
Premiums and discounts on available-for-sale marketable securities
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Related Party Transactions [Abstract]
Non Cash Research And Development Expense, Total
Non cash research and development expense.
Non Cash Research And Development Expense
Non-cash research and development expense
Vertex Agreement.
Vertex Agreement [Member]
Vertex Agreement
Exercisable at March 31, 2022
Exercisable at September 30, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
Amortization expense related to right-of-use assets
Finance Lease, Right-of-Use Asset, Amortization
Commitments and Contingencies Disclosure [Abstract]
Sanofi collaboration arrangement.
Sanofi Collaboration Arrangement [Member]
Sanofi Agreement
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Vested
Assets
Total assets
Fair Value, Inputs, Level 2 [Member]
Level 2
Investments and Cash
Cash, cash equivalents and marketable securities
Investments and Cash, Total
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Exercise of stock options, Shares
Exercised
Statement [Line Items]
Statement [Line Items]
Liabilities and Equity
Total liabilities and stockholders’ equity
Document Quarterly Report
Document Quarterly Report
Balance Sheet Location [Domain]
Balance Sheet Location
Billed receivables - Sanofi.
Billed Receivables Sanofi [Member]
Billed Receivables - Sanofi
Available-for-sale Securities, Current
Short-term investments
Available-for-sale Securities, Current, Total
Property, Plant and Equipment [Abstract]
Statement of Cash Flows [Abstract]
2025
Finance Lease, Liability, to be Paid, Year Three
2024
Vertex Pharmaceuticals Incorporated.
Vertex Pharmaceuticals Incorporated [Member]
Vertex Pharmaceuticals Incorporated
Additional Paid-in Capital [Member]
Additional Paid In Capital
Title of 12(b) Security
Title of 12(b) Security
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Total comprehensive loss
Fair Value, Inputs, Level 3 [Member]
Level 3
Award Type [Domain]
Award Type
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
2023
Finance Lease, Liability, to be Paid, Year One
2022
2024
Finance Lease, Liability, to be Paid, Year Two
2023
Property, Plant and Equipment [Table Text Block]
Summary of Property and Equipment
Fair Value, Inputs, Level 1 [Member]
Level 1
Increase (decrease) in contract with customer asset related parties.
Increase Decrease In Contract With Customer Asset Related Parties
Contract asset—due from related parties
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type
2026
Lessee, Operating Lease, Liability, to be Paid, Year Four
2025
Restricted Stock [Member]
Restricted Stock
Unvested Restricted Stock
IRAK4.
I R A K4 [Member]
IRAK4 Program
Fair Value, by Balance Sheet Grouping [Table]
Fair Value By Balance Sheet Grouping [Table]
Area of Real Estate Property
Area of office space
Corporate Debt Securities [Member]
Corporate Securities
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
Granted
Entity Current Reporting Status
Entity Current Reporting Status
Collaborative Arrangement Disclosure [Text Block]
Collaborations
Investment Type [Axis]
Investment Type
Marketable Securities [Table]
Marketable Securities [Table]
Revenue, Remaining Performance Obligation, Amount
Unsatisfied performance obligation
Noncash Investing and Financing Items [Abstract]
Supplemental disclosure of noncash investing and financing activities
Fair value assets level 3 to level 2 transfers amount.
Fair Value Assets Level3 To Level2 Transfers Amount
Fair value assets, level 3 to level 2 transfers, amount
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Fair Value Balance Sheet Grouping Financial Statement Captions [Line Items]
Money Market Funds [Member]
Money Market Fund
Granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Debt securities available for sale decline in market value for unrealized loss position number of securities.
Debt Securities Available For Sale Decline In Market Value For Unrealized Loss Position Number Of Securities
Number of securities decline in market value for in an unrealized loss position
Extended research term of collaboration.
Extended Research Term Of Collaboration
Extended research term of collaboration
Supplemental disclosure of noncash operating activities.
Supplemental Disclosure Of Noncash Operating Activities [Abstract]
Supplemental disclosure of noncash operating activities
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Equity-Based Compensation Expense
2022 (excluding the first quarter)
2021 (excluding the first, second and third quarter)
Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year
Computer Equipment [Member]
Computer Equipment
Lease additional term.
Lease Additional Term
Lease additional term
Accumulated Other Comprehensive Gain (Loss)
AOCI Attributable to Parent [Member]
Increase in accumulated deficit related to temporary equity deemed dividend.
Increase In Accumulated Deficit Related To Temporary Equity Deemed Dividend
Increase in accumulated deficit related to temporary equity deemed dividend
Exchange of convertible preferred stock impact on equity.
Exchange Of Convertible Preferred Stock Impact On Equity
Exchange of Series A Convertible Preferred Stock for Series C Preferred Convertible Preferred Stock
Two thousand and twenty plan.
Two Thousand And Twenty Plan [Member]
2020 Plan
Income Statement Location [Domain]
Income Statement Location
Potential receivable milestone payments.
Potential Receivable Milestone Payments
Eligible to receive payments including development, regulatory and commercial milestones
Contract with customer asset net additions.
Contract With Customer Asset Net Additions
Accounts receivable and contract assets, Additions
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Exercisable at March 31, 2021
Exercisable at September 30, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Increase (Decrease) in Accrued Liabilities
Accrued expenses and other current liabilities
Increase (Decrease) in Accrued Liabilities, Total
Minimum [Member]
Minimum
Measurement Frequency [Domain]
Measurement Frequency
Security Deposit
Security deposit
Royalty receivable.
Royalty Receivable
Royalty receivable
Lesser of potential outcome two.
Lesser Of Potential Outcome Two [Member]
Lesser of Potential Outcome 2
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options
Finance Lease, Liability, Noncurrent
Finance lease liabilities, net of current portion
Granted
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Granted
Income tax disclosure.
Income Tax Disclosure [Table]
Income Tax Disclosure [Table]
Lease term.
Lease Term
Lease term
Lessee, Operating Lease, Liability, Payment, Due [Abstract]
Operating Leases
Lessee operating and financing lease liability maturity.
Lessee Operating And Financing Lease Liability Maturity Table [Text Block]
Summary of Undiscounted Future Lease Payments for Operating and Finance Leases
Proceeds from issuance initial public offering gross.
Proceeds From Issuance Initial Public Offering Gross
Gross proceeds from issuance initial public offering
Project [Domain]
Project
Net Cash Provided by (Used in) Financing Activities [Abstract]
Financing activities
Impairment of Leasehold
Reduction of right-of-use asset and liability due to lease modification
Entity Filer Category
Entity Filer Category
Document Fiscal Year Focus
Document Fiscal Year Focus
Series B convertible preferred stock.
Series B Convertible Preferred Stock [Member]
Series B Convertible Preferred Stock
Series B Preferred Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Unbilled receivables - Sanofi.
Unbilled Receivables Sanofi [Member]
Unbilled Receivables - Sanofi
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average fair value of options granted
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Income Tax Disclosure [Text Block]
Income Taxes
Noncancelable facility lease agreement.
Noncancelable Facility Lease Agreement [Member]
Noncancelable Facility Lease Agreement
Entity Ex Transition Period
Entity Ex Transition Period
Fair Value Disclosures [Abstract]
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment
Maximum [Member]
Maximum
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Change in Accounts Receivable, Contract Asset and Liabilities
Entity Central Index Key
Entity Central Index Key
Series seed convertible preferred stock.
Series Seed Convertible Preferred Stock [Member]
Series Seed Convertible Preferred Stock
Temporary Equity [Line Items]
Temporary Equity [Line Items]
Temporary Equity Disclosure [Abstract]
Entity Tax Identification Number
Entity Tax Identification Number
Equity Component [Domain]
Equity Component
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Contract with customer liability additions.
Contract With Customer Liability Additions
Contract Liabilities, Additions
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Volatility
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Reconciliation of net loss to net loss attributable to common stockholders:
Debt Securities, Available-for-sale [Table Text Block]
Summary of Available-for-Sale Debt Securities
Proceeds from Issuance of Private Placement
Aggregate proceeds from issuance of private placement
Stockholders' Equity Note, Stock Split, Conversion Ratio
Reverse stock split
Stock split, conversion ratio
Temporary Equity, Dividends, Adjustment
Deemed dividend from exchange of convertible preferred stock
Deemed dividend from exchange of convertible preferred stock
Assets not yet in service.
Assets Not Yet In Service [Member]
Assets Not Yet in Service
Interest and other expense
Other Nonoperating Expense
Other Nonoperating Expense, Total
Finance Lease, Weighted Average Remaining Lease Term
Finance lease, remaining lease term
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized compensation cost, recognition period
US Government Corporations and Agencies Securities [Member]
US Government Corporations and Agencies Securities [Member]
Reduction of right of use asset and liability due to lease modification.
Reduction Of Right Of Use Asset And Liability Due To Lease Modification
Reduction of right-of-use asset and liability due to lease modification
Consolidated Entities [Axis]
Consolidated Entities
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Accounting standards update, adoption date
Subsequent Events [Abstract]
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Leasehold Improvements [Member]
Leasehold Improvements
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Number of shares authorized for issuance under plan
Cambridge, Massachusetts.
Cambridge Massachusetts [Member]
Cambridge, Massachusetts
Statement [Table]
Statement [Table]
Operating Lease, Weighted Average Remaining Lease Term
Operating lease, remaining lease term
Project [Axis]
Project
Entity File Number
Entity File Number
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Retained Earnings [Member]
Accumulated Deficit
Accounting Standards Update [Domain]
Accounting Standards Update
Accounting Standards Update [Axis]
Accounting Standards Update
Revenue from Contract with Customer, Excluding Assessed Tax
Collaboration Revenue—from related parties
Revenue recognized
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Payments of Stock Issuance Costs
Underwriting discounts, offering costs and issuance costs
Stock issuance costs
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Liabilities, Current [Abstract]
Current liabilities:
Share-based Payment Arrangement [Text Block]
Equity-Based Compensation
Subsequent Event [Member]
Subsequent Events
Finance Lease, Liability, Current
Finance lease liabilities
Commitments and Contingencies Disclosure [Text Block]
Other Commitments and Contingencies
Operating Lease, Liability
Present value of lease liabilities
Operating Lease, Liability, Total
Share based compensation arrangement by share based payment award options forfeited in period intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeited In Period Intrinsic Value
Forfeited
Common Stock [Member]
Common Stock
Property, Plant and Equipment, Gross
Total property and equipment
Property and equipment right of use assets under finance leases with cost basis
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Accrued Professional Fees, Current
Professional fees
Scenario potential outcome.
Scenario Potential Outcome [Axis]
Scenario Potential Outcome
Lease commencement date
Lease commencement date.
Lease Commencement Date
Cover [Abstract]
Credit Facility [Domain]
Credit Facility
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Unvested at end of period
Unvested at beginning of period
Temporary Equity, Shares Outstanding
Temporary Equity, Ending Balance, Shares
Temporary Equity, Beginning Balance, Shares
Convertible Preferred Stock, outstanding
Statement of Stockholders' Equity [Abstract]
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Equity-Based Compensation
Share-based Payment Arrangement [Abstract]
Facility sublease agreement.
Facility Sublease Agreement [Member]
Facility Sublease Agreement
2026
Finance Lease, Liability, to be Paid, Year Four
2025
Series B-1 convertible preferred stock.
Series B1 Convertible Preferred Stock [Member]
Series B-1 Convertible Preferred Stock
Net operating loss carryforwards period CARES Act.
Net Operating Loss Carryforwards Period C A R E S Act
Net operating loss carryforwards period CARES Act
Series A Preferred Units.
Series A Preferred Units [Member]
Series A Preferred Units
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Other Accrued Liabilities, Current
Other
Document Transition Report
Document Transition Report
Collaboration target one.
Collaboration Target One [Member]
Collaboration Target 1
Proceeds from Stock Options Exercised
Proceeds from stock option exercises
Letter of Credit [Member]
Letter of Credit
Research and Development Expense
Research and development
Research and Development Expense, Total
Contract with Customer, Liability, Noncurrent
Deferred revenue, net of current portion
Follow-on offering.
Follow On Offering [Member]
Follow-on Offering
Share-based Payment Arrangement, Expense
Equity-based compensation expense
Total equity-based compensation
Debt securities, available-for-sale, contractual maturity of less than 12 months, number of securities.
Debt Securities Available For Sale Contractual Maturity Of Less Than12 Months Number Of Securities
Number of available-for-sale debt securities, contractual maturity of less than 12 months
Statement of Financial Position [Abstract]
Restricted cash.
Restricted Cash [Member]
Restricted Cash
Significant accounting policies.
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Dividend yield
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested
2020 Employee stock purchase plan.
Two Thousand Twenty Employee Stock Purchase Plan [Member]
2020 ESPP
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation, Depletion and Amortization, Total
Lease Contractual Term [Axis]
Unbilled Contracts Receivable
Unbilled accounts receivable
Deferred revenue - Sanofi.
Deferred Revenue Sanofi [Member]
Deferred Revenue - Sanofi
Stockholders' Equity Attributable to Parent [Abstract]
Stockholders’ equity:
Conversion of Stock, Shares Converted
Number of preferred Stock converted to common stock
Temporary equity stock shares vesting of series A preferred stock in connection with collaboration arrangement.
Temporary Equity Stock Shares Vesting Of Series A Preferred Stock In Connection With Collaboration Arrangement
Vesting of Series A Preferred Stock in connection with collaboration arrangement (Note 5), Shares
Number of shares vested
Weighted Average Remaining Contractual Term (in years)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]
Lease Contractual Term [Domain]
Accrued research and development expenses current.
Accrued Research And Development Expenses Current
Research and development expenses
Payments to Acquire Investments
Purchases of investments
Payments to Acquire Investments, Total
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Summary of Basic and Diluted Loss Per Share
Exercised
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
2024
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Measurement Frequency [Axis]
Measurement Frequency
Award Type [Axis]
Award Type
Collaboration termination date
Collaboration Termination Date
Collaboration termination date.
Written notice period to terminate collaboration agreement.
Written Notice Period To Terminate Collaboration Agreement
Written notice period to terminate collaboration agreement
Entity Shell Company
Entity Shell Company
Sale of Stock, Price Per Share
Common stock per share
Stock issued price per share
Compound Collaboration Agreement.
Compound Collaboration Agreement [Member]
Compound Collaboration
Liabilities and Equity [Abstract]
Liabilities and Stockholders’ Equity
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of shares under employee stock purchase plan
Earnings Per Share [Text Block]
Net Loss per Share
Temporary equity, exchange of convertible preferred stock, value.
Temporary Equity Exchange Of Convertible Preferred Stock Value
Temporary Equity, Exchange of Series A Convertible Preferred Stock for Series C Preferred Convertible Preferred Stock
Liabilities, Noncurrent [Abstract]
Non-current liabilities
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Number of Units Outstanding
Amendment Flag
Amendment Flag
Finance Lease, Principal Payments
Financing cash flows used in finance leases
Other Nonoperating Income (Expense)
Total other income:
Lessee operating lease liability payments due after year four.
Lessee Operating Lease Liability Payments Due After Year Four
Thereafter
Fair value assets level 2 to Level 3 transfers amount.
Fair Value Assets Level2 To Level3 Transfers Amount
Fair value assets, level 2 to level 3 transfers, amount
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Interest and other Income
Other Nonoperating Income
New Accounting Pronouncements, Policy [Policy Text Block]
Recent Accounting Pronouncements
Marketable Securities [Abstract]
Unrecognized stock-based compensation expense
Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Supplemental cash flow information relating to leases.
Supplemental Cash Flow Information Relating To Leases Table [Text Block]
Supplemental Cash Flow Information Relating to Leases
Marketable securities, current
Marketable Securities, Current
Marketable Securities, Current, Total
Fair Value, Recurring [Member]
Fair Value, Recurring
Annual increase percentage of rent
Base Rent Annual Increase Over The Lease Term
Base rent annual increase over the lease term.
Subsequent Events [Text Block]
Subsequent Events
Fair Value, Assets, Level 1 to Level 2 Transfers, Amount
Fair value, assets, level 1 to level 2 transfers, amount
Tax Period [Domain]
Tax Period
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Other Assets, Noncurrent
Other non-current assets
Other Assets, Noncurrent, Total
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Loss Contingency Nature [Axis]
Loss Contingency Nature
Geographical [Domain]
Geographical
Customer [Domain]
Exercisable at March 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value
Exercisable at September 30, 2021
Prepaid Expenses and Other Current Assets [Member]
Prepaid Expenses and Other Current Assets
Corporate Bond Securities [Member]
Corporate Bonds
Sale of Stock [Axis]
Sale of Stock
Fair Value Disclosures [Text Block]
Fair Value Measurements
Share-based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation expense
Proceeds from Issuance of Common Stock
Net proceeds from sale of common stock in public offering
Gross proceeds from issuance of common stock